Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • US: Not FDA approved
  • In general: ℞ (Prescription only)
  • 2-Dimethylaminoethyl (4-chlorophenoxy)acetate
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.107 Edit this at Wikidata
Chemical and physical data
Molar mass257.71 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)OCC(=O)OCCN(C)C
  • InChI=1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3 ☒N
 ☒NcheckY (what is this?)  (verify)

Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement.[1][2][3][self-published source?] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests.[4] Meclofenoxate also increases cellular membrane phospholipids.[citation needed] It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.[3]

Side effects

Meclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.[3]


Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.[5][6]

Brand names

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[7]

See also


  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
  3. ^ a b c d Haavisto M (1 May 2008). Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia. pp. 167–. ISBN 978-1-4092-0335-3.[self-published source]
  4. ^ Marcer D, Hopkins SM (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
  5. ^ Donaldson T (1 January 2003). "A Brief History of Anti-aging Drugs". In Klatz R, Goldman B (eds.). The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. pp. 66–. ISBN 978-0-9668937-3-1.
  6. ^ Hothschild R (August 1973). "Effect of dimethylamnioethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimental Gerontology. 8 (4): 177–183. doi:10.1016/0531-5565(73)90024-7. PMID 4147092.
  7. ^ Zhou Y (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.