Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
  • 2-(diethylamino)ethyl hydroxy(diphenyl)acetate
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.005.568 Edit this at Wikidata
Chemical and physical data
Molar mass327.424 g·mol−1
3D model (JSmol)
  • O=C(OCCN(CC)CC)C(O)(c1ccccc1)c2ccccc2
  • InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3 checkY
 ☒NcheckY (what is this?)  (verify)

Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness.[1]

Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.[1] "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD."[2]

Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence of effectiveness when combined with meprobamate, with the medication no longer available it is not clinically important.[3]


Benactyzine was brought to market in the US in 1957 by Merck under the tradename, Suavitil.[4]


  1. ^ a b Shorter E (December 2002). "Looking backwards: a possible new path for drug discovery in psychopharmacology". Nature Reviews. Drug Discovery. 1 (12): 1003–1006. doi:10.1038/nrd964. PMID 12461521. S2CID 23439533.
  2. ^ Fisher S (1959). Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.
  3. ^ DeBattista AF, Schatzberg JO, Cole C (2010). Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 978-1-58562-377-8.
  4. ^ Smith MC (2013). "Market Behavior". Principles of Pharmaceutical Marketing (Third ed.). New York: Routledge. ISBN 978-1-317-94071-5.