Clinical data
ATC code
  • none
  • 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass317.429 g·mol−1
3D model (JSmol)
  • c1ccccc1C2(CCCCC2)C(=O)OCCN3CCOCC3
  • InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2 ☒N
 ☒NcheckY (what is this?)  (verify)

PRE-084 is a sigma receptor agonist, selective for the σ1 subtype. It has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects.[1][2][3][4][5] PRE-084 increases the expression of GDNF.[6]


  1. ^ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994). "PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice". Pharmacology Biochemistry and Behavior. 49 (4): 859–69. doi:10.1016/0091-3057(94)90235-6. PMID 7886099. S2CID 54306053.
  2. ^ Maurice T (November 2001). "Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats". European Journal of Pharmacology. 431 (2): 223–7. doi:10.1016/S0014-2999(01)01436-4. PMID 11728429.
  3. ^ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004). "Antitussive activity of sigma-1 receptor agonists in the guinea-pig". British Journal of Pharmacology. 141 (2): 233–40. doi:10.1038/sj.bjp.0705605. PMC 1574192. PMID 14691051.
  4. ^ Skuza G, Rogóz Z (2009). "Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice". Pharmacological Reports. 61 (6): 1179–83. doi:10.1016/S1734-1140(09)70181-1. PMID 20081254. S2CID 96025873.
  5. ^ Hiranita T, Soto PL, Tanda G, Katz JL (February 2010). "Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine". The Journal of Pharmacology and Experimental Therapeutics. 332 (2): 515–24. doi:10.1124/jpet.109.159236. PMC 2812106. PMID 19892920.
  6. ^ Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X (May 2011). "Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury". J. Neurotrauma. 28 (5): 831–40. doi:10.1089/neu.2010.1674. PMID 21332255.