Clinical data
ATC code
  • none
  • 3,3-bis(3-fluorophenyl)-N-methylpropan-1-amine
CAS Number
PubChem CID
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Chemical and physical data
Molar mass261.316 g·mol−1
3D model (JSmol)
  • CNCCC(C1=CC(=CC=C1)F)C2=CC(=CC=C2)F
  • InChI=1S/C16H17F2N/c1-19-9-8-16(12-4-2-6-14(17)10-12)13-5-3-7-15(18)11-13/h2-7,10-11,16,19H,8-9H2,1H3 ☒N
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Delucemine (NPS-1506) is a drug which acts as an NMDA antagonist and a serotonin reuptake inhibitor, and has neuroprotective effects.[1][2] It was originally investigated for the treatment of stroke and in 2004 was studied as a potential antidepressant.[3][4][5]


The basic structure of Delucemine was based on argiotoxin 636, a NMDA antagonist isolated from the venom of the Araneid Argiope aurantia.[6][7][8]

See also


  1. ^ Mueller AL, Artman LD, Balandrin MF, Brady E, Chien Y, Delmar EG, et al. (December 1999). "NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies". Annals of the New York Academy of Sciences. 890: 450–7. doi:10.1111/j.1749-6632.1999.tb08023.x. PMID 10668449. S2CID 5629889.
  2. ^ Leoni MJ, Chen XH, Mueller AL, Cheney J, McIntosh TK, Smith DH (December 2000). "NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat". Experimental Neurology. 166 (2): 442–9. doi:10.1006/exnr.2000.7513. PMID 11085909. S2CID 39222349.
  3. ^ "NPS Pharmaceuticals Inc, Form 10-Q, Quarterly Report, Filing Date May 17, 2004". Retrieved May 14, 2018.
  4. ^ CA 2599721, Pyke R, Ceci A, "Pharmaceutical compositions for the treatment and/or prevention of depression" 
  5. ^ WO 2014015047, Ichinose F, Marutani E, Kida K, "Compositions and methods to treat neurodegenerative diseases" 
  6. ^ Nentwig W (2013-02-15). Spider Ecophysiology. Springer Science & Business Media. ISBN 9783642339899.
  7. ^ Oldrati V, Bianchi E, Stöcklin R (February 2013). "Spider Venom Components as Drug Candidates". Spider Ecophysiology. pp. 491–503. doi:10.1007/978-3-642-33989-9_37. ISBN 978-3-642-33988-2. ((cite book)): Missing or empty |title= (help)
  8. ^ Monge-Fuentes V, Gomes FM, Campos GA, Silva Jd, Biolchi AM, Dos Anjos LC, et al. (August 2015). "Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders". The Journal of Venomous Animals and Toxins Including Tropical Diseases. 21 (31): 31. doi:10.1186/s40409-015-0031-x. PMC 4529710. PMID 26257776.