DNQX
Skeletal formula
Space-filling model of DNQX
Names
Preferred IUPAC name
6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione
Identifiers
3D model (JSmol)
ChemSpider
DrugBank
UNII
  • InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) checkY
    Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N checkY
  • InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
    Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N
  • O=c2[nH]c1cc(N(=O)=O)c(N(=O)=O)cc1[nH]c2=O
Properties
C8H4N4O6
Molar mass 252.142 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies.[1] It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.

See also

References

  1. ^ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R (September 2010). "Glutamate receptor ion channels: structure, regulation, and function". Pharmacological Reviews. 62 (3): 405–96. doi:10.1124/pr.109.002451. PMC 2964903. PMID 20716669.