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Other names | TAK-906; ATC-1906 |
Drug class | Dopamine antagonist |
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Formula | C31H39N3O4 |
Molar mass | 517.670 g·mol−1 |
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Trazpiroben (developmental code name TAK-906) is a dopamine antagonist drug which was under development for the treatment of gastroparesis.[1][2][3][4][5] It acts as a peripherally selective dopamine D2 and D3 receptor antagonist.[1][2] The drug has been found to strongly increase prolactin levels in humans, similarly to other peripherally selective D2 receptor antagonists like domperidone.[5] Clinical development of trazpiroben was discontinued before April 2022.[1] Trazpiroben was originated by Altos Therapeutics and was under development by Takeda Oncology.[1]