• 3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass295.382 g·mol−1
3D model (JSmol)
  • c3ccccc3C2CN(CC=C)CCc(cc1O)c2cc1O
  • InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2

SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]


  1. ^ Grech DM, Spealman RD, Bergman J (May 1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology. 125 (2): 97–104. doi:10.1007/BF02249407. PMID 8783382. S2CID 36378721.
  2. ^ Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL (October 1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID 9336305.
  3. ^ Platt DM, Rowlett JK, Spealman RD (June 2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–26. PMID 10869406.
  4. ^ Platt DM, Rowlett JK, Spealman RD (September 2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208–16. doi:10.1007/s002130100779. PMID 11594448. S2CID 6567384.
  5. ^ Mutschler NH, Bergman J (April 2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362–70. doi:10.1007/s00213-001-0976-z. PMID 11919663. S2CID 20483120.
  6. ^ Desai RI, Terry P, Katz JL (August 2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior. 81 (4): 843–8. doi:10.1016/j.pbb.2005.06.006. PMID 16000217. S2CID 2525256.
  7. ^ Katz JL, Kopajtic TA, Terry P (June 2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303–9. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948. S2CID 24288989.