Tiflorex
Tiflorex.svg
Clinical data
ATC code
  • none
Identifiers
  • (RS)-N-ethyl-1-{3-[(trifluoromethyl)thio]phenyl}propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H16F3NS
Molar mass263.32 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • CCNC(C)Cc1cccc(c1)SC(F)(F)F
  • InChI=1S/C12H16F3NS/c1-3-16-9(2)7-10-5-4-6-11(8-10)17-12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3 ☒N
  • Key:HNONSDNCRNUTCT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tiflorex, formerly known as flutiorex, is a stimulant amphetamine. Its most pronounced effect is in suppression of appetite; it has little effect on pulse rate, sleep, or mood.[1] It was found to be twice as potent an anorectic as fenfluramine.[2]

SL 72.340-d was cited to be 4x the anorectant potency of fenfluramine (ED50=1.4 mg/kg vs 5.6 mg/kg).[3]

References

  1. ^ Silverstone T, Fincham J, Plumley J (April 1979). "An evaluation of the anorectic activity in man of a sustained release formulation of tiflorex". British Journal of Clinical Pharmacology. 7 (4): 353–6. doi:10.1111/j.1365-2125.1979.tb00945.x. PMC 1429648. PMID 444355.
  2. ^ Giudicelli JF, Richer C, Berdeaux A (February 1976). "Preliminary assessment of flutiorex, a new anorectic drug, in man". British Journal of Clinical Pharmacology. 3 (1): 113–21. doi:10.1111/j.1365-2125.1976.tb00578.x. PMC 1428817. PMID 788737.
  3. ^ Stuart S (2013-09-11). Abstracts: Sixth International Congress of Pharmacology. ISBN 9781483152530.