Eltoprazine
Clinical data
Other namesDU-28,853
ATC code
  • none
Identifiers
  • 1-(2,3-dihydro-1,4-benzodioxin-8-yl)piperazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H16N2O2
Molar mass220.272 g·mol−1
3D model (JSmol)
  • C1CN(CCN1)C2=C3C(=CC=C2)OCCO3

Eltoprazine (developmental code name DU-28,853) is a serotonergic drug of the phenylpiperazine class which is a serenic or antiaggressive agent.[1] It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.[2] It is closely related to fluprazine and batoprazine, which are similarly acting drugs.

It is also a known chemical precursor to S-15535 and lecozotan.

References

  1. ^ Olivier B, Mos J, Rasmussen D (1990). "Behavioural pharmacology of the serenic, eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 31–83. doi:10.1515/DMDI.1990.8.1-2.31. PMID 2091890. S2CID 27279453.
  2. ^ Schipper J, Tulp MT, Sijbesma H (1990). "Neurochemical profile of eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 85–114. doi:10.1515/dmdi.1990.8.1-2.85. PMID 1982626. S2CID 30096596.