|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||190.246 g·mol−1|
|3D model (JSmol)|
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.
5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. It has no affinity for the 5-HT3 receptor and its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors. Its affinity for the 5-HT5A receptor is unknown.
Measured affinity for some receptors (not a complete list):