Ro 04-6790
Clinical data
ATC code
  • none
  • 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
CAS Number
PubChem CID
Chemical and physical data
Molar mass308.36 g·mol−1
3D model (JSmol)
  • Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1
  • InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)

Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT6 serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,[1] Ro 04-6790 has nootropic effects in animals,[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine[3] and scopolamine.[4]


  1. ^ Fone KC (November 2008). "An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function". Neuropharmacology. 55 (6): 1015–22. doi:10.1016/j.neuropharm.2008.06.061. PMID 18655798. S2CID 35522597.
  2. ^ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC (January 2009). "Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task". Psychopharmacology. 202 (1–3): 111–23. doi:10.1007/s00213-008-1334-1. PMID 18839151. S2CID 10826081.
  3. ^ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N (April 2008). "The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801". Behavioural Brain Research. 188 (2): 304–9. doi:10.1016/j.bbr.2007.11.010. PMID 18164078. S2CID 40183481.
  4. ^ Woolley ML, Marsden CA, Sleight AJ, Fone KC (December 2003). "Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790" (PDF). Psychopharmacology. 170 (4): 358–67. doi:10.1007/s00213-003-1552-5. PMID 13680084. S2CID 25193679.