The antiparasitic drug ivermectin
(shown here in royal blue) works by binding to glutamate-gated chloride channel receptors, a type of chloride channel found only in protostomes
. It “locks” the receptor in an activated (open) conformation, allowing unrestricted passage of chloride (Cl−
) ions into the cell, ultimately killing the parasite.
(Top view shows the open channel, with a central pore through which Cl−
is transported; side view shows drug binding. From PDB: 3RHW
A chloride channel opener is a type of drug which facilitates ion transmission through chloride channels.
An example is 1,10-phenanthroline, which activates Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels.
GABA-A receptor agonists (e.g. lorazepam) may also be considered chloride channel openers