Protein-coding gene in the species Homo sapiens
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene .[5] [6]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[7]
Interactions
CLTC has been shown to interact with PICALM [8] and HGS .[9]
^ a b c GRCh38: Ensembl release 89: ENSG00000141367 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047126 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics . 11 (1): 174–8. doi :10.1016/0888-7543(91)90115-U . PMID 1765375 .
^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35. doi :10.1093/dnares/1.1.27 . PMID 7584026 .
^ "Entrez Gene: CLTC clathrin, heavy chain (Hc)" .
^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" . Mol. Biol. Cell . 10 (8): 2687–702. doi :10.1091/mbc.10.8.2687 . ISSN 1059-1524 . PMC 25500 . PMID 10436022 .
^ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes" . EMBO J . 20 (17): 5008–21. doi :10.1093/emboj/20.17.5008 . ISSN 0261-4189 . PMC 125612 . PMID 11532964 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
PDB gallery
PDB gallery
1b89 : CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)
1bpo : CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER
1c9i : PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1c9l : PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1utc : CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT
Membrane protein: vesicular transport proteins (TC 1F)