Route 101 or Highway 101 can refer to multiple roads:

International

• E101 European route E101

Argentina

• National Route 101

Australia

• Southern Ports Highway
• Princes Highway (East)

Brazil

• BR-101

Canada

• British Columbia Highway 101
• Manitoba Highway 101 (Perimeter Highway)
• New Brunswick Route 101
• Newfoundland and Labrador Route 101
• Nova Scotia Highway 101
• Ontario Highway 101
• Prince Edward Island Route 101
• Quebec Route 101

China

• National Highway 101

Costa Rica

• National Route 101

Ireland

• R101 road (North Circular Road, Dublin)

Japan

• Japan National Route 101

Mexico

• Mexican Federal Highway 101

Nigeria

• F101 highway (Nigeria)

Philippines

• N101 highway (Philippines)

Puerto Rico

• Puerto Rico Highway 101

Russia

• Russian route A130, formerly A101

United Kingdom

• A101, Rotherhithe Tunnel

United States

• U.S. Route 101
• Alabama State Route 101
• Arizona State Route 101
• Arkansas Highway 101
• Colorado State Highway 101
• Connecticut Route 101
• Florida State Road 101
  • County Road 101A (Duval County, Florida)
• Georgia State Route 101
• Illinois Route 101
• Indiana State Road 101
• K-101 (Kansas highway)
• Kentucky Route 101
• Louisiana Highway 101
• Maine State Route 101
• Maryland Route 101 (former)
• Massachusetts Route 101
• M-101 (Michigan highway) (former)
• Minnesota State Highway 101
  • County Road 101 (Hennepin County, Minnesota)
  • County Road 101 (Scott County, Minnesota)
• Missouri Route 101
  • Missouri Route 101 (1929) (former)
• Nebraska Highway 101 (former)
• New Hampshire Route 101
  • New Hampshire Route 101A
  • New Hampshire Route 101B (former)
  • New Hampshire Route 101C (former)
  • New Hampshire Route 101D (former)
  • New Hampshire Route 101E
• New Jersey Route 101 (former)
  • County Route 101 (Bergen County, New Jersey)
  • County Route 101 (Ocean County, New Jersey)
• New Mexico State Road 101
• New York State Route 101
  • County Route 101 (Cattaraugus County, New York)
  • County Route 101 (Cayuga County, New York)
  • County Route 101 (Cortland County, New York)
  • County Route 101 (Dutchess County, New York)
  • County Route 101 (Fulton County, New York)
  • County Route 101 (Nassau County, New York)
  • County Route 101 (Orleans County, New York)
  • County Route 101 (Seneca County, New York)
  • County Route 101 (Suffolk County, New York)
  • County Route 101 (Tompkins County, New York)
  • County Route 101 (Wayne County, New York)
• North Carolina Highway 101
• Ohio State Route 101
• Oklahoma State Highway 101
• Pennsylvania Route 101 (former)
• Rhode Island Route 101
• South Carolina Highway 101
• South Dakota Highway 101
• Tennessee State Route 101
• Texas State Highway 101
  • Texas State Highway Spur 101 (former)
  • Farm to Market Road 101
• Utah State Route 101
• Vermont Route 101
• Virginia State Route 101
• West Virginia Route 101
• Wisconsin Highway 101

Territories

• Puerto Rico Highway 101

Uruguay

• Route 101