The following highways are numbered 50:

International

• E50 European route E50

Brazil

• BR-050

Canada

• Alberta Highway 50
• Manitoba Highway 50
• Newfoundland and Labrador Route 50
• Ontario Highway 50 (Also referred to as Peel Regional Road 50 and York Regional Road 24)
• Quebec Autoroute 50

China

• G50 Expressway

Czech Republic

• I/50 Highway; Czech: Silnice I/50

Finland

• Ring III (Kt 50)

India

• NH 50, a National Highway between Pune and Nashik cities

Ireland

• M50 motorway (Ireland)

Israel

• Begin Expressway Highway 50 (Israel). A freeway in Jerusalem, Israel.

Italy

• Autostrada A50

Japan

• Japan National Route 50

Jordan

• Highway 50

Korea, South

• Yeongdong Expressway
• National Route 50

Malaysia

• FT 50 Malaysia Federal Route 50

New Zealand

• New Zealand State Highway 50

Poland

• DK50, a national road functioning as a transit ring road around Warsaw
• motorway A50, planned motorway being a part of new ring road around Warsaw
• expressway S50, planned expressway being a part of new ring road around Warsaw

Turkey

• O-50, a motorway in Turkey as the half ring road in Adana.

United Kingdom

• British A50 (Leicester-Warrington)
• British M50 (Strensham-Ross on Wye)

United States

• Interstate 50 (North Carolina–Virginia) (former proposal)
• U.S. Route 50
  • U.S. Route 50N (Kansas) (former)
  • U.S. Route 50N (Ohio–West Virginia) (former)
  • U.S. Route 50S (Kansas) (former)
  • U.S. Route 50S (Ohio–West Virginia) (former)
• Alabama State Route 50
• Arizona State Route 50 (never built)
• Arkansas Highway 50
• Colorado State Highway 50 (1923-1968) (former)
• Florida State Road 50
  • Florida State Road 50A
• Georgia State Route 50
  • Georgia State Route 50N (former)
  • Georgia State Route 50S (former)
• Hawaii Route 50
• Idaho State Highway 50
• Illinois Route 50
• Iowa Highway 50 (former)
• Kentucky Route 50 (former)
• Louisiana Highway 50
  • Louisiana State Route 50 (former)
• M-50 (Michigan highway)
• Minnesota State Highway 50
  • County Road 50 (Dakota County, Minnesota)
  • County Road 50 (Ramsey County, Minnesota)
• Mississippi Highway 50
• Missouri Route 50 (1922) (former)
• Montana Highway 50 (former)
• Nebraska Highway 50
  • Nebraska Link 50A
  • Nebraska Recreation Road 50B
  • Nebraska Recreation Road 50C
• Nevada State Route 50 (1935) (former)
• New Jersey Route 50
  • County Route 50 (Bergen County, New Jersey)
  • County Route 50 (Monmouth County, New Jersey)
  • County Route 50 (Ocean County, New Jersey)
• New Mexico State Road 50
• New York State Route 50
  • County Route 50 (Cattaraugus County, New York)
  • County Route 50 (Cayuga County, New York)
  • County Route 50 (Chautauqua County, New York)
  • County Route 50 (Dutchess County, New York)
  • County Route 50 (Erie County, New York)
  • County Route 50 (Greene County, New York)
  • County Route 50 (Monroe County, New York)
  • County Route 50A (Oneida County, New York)
  • County Route 50 (Onondaga County, New York)
  • County Route 50 (Ontario County, New York)
  • County Route 50 (Otsego County, New York)
  • County Route 50 (Putnam County, New York)
  • County Route 50 (Rensselaer County, New York)
  • County Route 50 (Schoharie County, New York)
  • County Route 50 (Suffolk County, New York)
    • County Route 50A (Suffolk County, New York)
    • County Route 50B (Suffolk County, New York)
    • County Route 50C (Suffolk County, New York)
  • County Route 50 (Ulster County, New York)
• North Carolina Highway 50
• North Dakota Highway 50
• Ohio State Route 50 (1923-1927) (former)
• Oklahoma State Highway 50
  • Oklahoma State Highway 50A
  • Oklahoma State Highway 50B
• Oregon Route 50 (former)
• Pennsylvania Route 50
• South Carolina Highway 50 (former, multiple)
• South Dakota Highway 50
• Tennessee State Route 50
• Texas State Highway 50
  • Texas State Highway Loop 50 (former)
  • Texas State Highway Spur 50 (former)
  • Farm to Market Road 50
  • Texas Park Road 50
• Utah State Route 50 (former, multiple)
• Virginia State Route 50 (former)
• Wisconsin Highway 50
• Wyoming Highway 50