The following highways are numbered 159:

Canada

• Prince Edward Island Route 159 (Peter Road)
• Quebec Route 159

Costa Rica

• National Route 159

Japan

• Japan National Route 159

United States

• U.S. Route 159
• Alabama State Route 159
• Arkansas Highway 159
• California State Route 159 (former)
• Colorado State Highway 159
• Connecticut Route 159
• Florida State Road 159
• Georgia State Route 159
• Illinois Route 159
• Indiana State Road 159
• Kentucky Route 159
• Louisiana Highway 159
• Maine State Route 159
• Maryland Route 159
• Massachusetts Route 159
• Nevada State Route 159
• New Jersey Route 159
• New Mexico State Road 159
• New York State Route 159
• North Carolina Highway 159
• Ohio State Route 159
• Pennsylvania Route 159 (former)
• Tennessee State Route 159
• Texas State Highway 159
  • Texas State Highway Spur 159
• Utah State Route 159
• Virginia State Route 159
• Wisconsin Highway 159
• Wyoming Highway 159

Territories

• Puerto Rico Highway 159

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