Protein-coding gene in the species Homo sapiens
Erythrocyte membrane protein band 4.2 is a protein that in humans is encoded by the EPB42 gene.[5][6] It is part of the red blood cell cytoskeleton.
Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of band 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia.[6]