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ECHA InfoCard | 100.164.583 ![]() |
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Formula | C21H30O3 |
Molar mass | 330.468 g·mol−1 |
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11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC, alternatively numbered as 7-OH-Δ1-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after THC is consumed.[1][2]
After Cannabis consumption, THC is metabolized inside the body by cytochrome P450 enzymes such as CYP2C9 and CYP3A4 into 11-hydroxy-THC and then further metabolized by dehydrogenase enzyme into 11-nor-9-carboxy-THC;[2] and further glucuronidated to form 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid glucuronide (delta-9-THC-COOH-glu)[3] where it's excreted in both feces and urine.[4] Both compounds, along with THC, can be assayed in drug tests.[1]
11-hydroxy-THC can be formed after consumption of THC from inhalation (vaping, smoking) and oral (by mouth, edible, sublingual) use, although levels of 11-hydroxy-THC are typically higher when eaten compared to inhalation.[5][6]
11-hydroxy-THC has a comparable psychoactive effect to THC, but with a faster onset of effect when used intravenously (injected directly into the bloodstream).[medical citation needed][7]
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