|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||330.468 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC, alternatively numbered as 7-OH-Δ1-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after THC is consumed.
After Cannabis consumption, THC is metabolized inside the body by cytochrome P450 enzymes such as CYP2C9 and CYP3A4 into 11-hydroxy-THC and then further metabolized by dehydrogenase enzyme into 11-nor-9-carboxy-THC; and further glucuronidated to form 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid glucuronide (delta-9-THC-COOH-glu) where it's excreted in both feces and urine. Both compounds, along with THC, can be assayed in drug tests.
11-hydroxy-THC can be formed after consumption of THC from inhalation (vaping, smoking) and oral (by mouth, edible, sublingual) use, although levels of 11-hydroxy-THC are typically higher when eaten compared to inhalation.
11-hydroxy-THC has a comparable psychoactive effect to THC, but with a faster onset of effect when used intravenously (injected directly into the bloodstream).[medical citation needed]