Clinical data | |
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AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
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ECHA InfoCard | 100.048.148 ![]() |
Chemical and physical data | |
Formula | C16H14O3 |
Molar mass | 254.285 g·mol−1 |
3D model (JSmol) | |
Melting point | 186 °C (367 °F) |
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Fenbufen is a nonsteroidal anti-inflammatory drug used to treat pain.[1]
Fenbufen is a member of the propionic acid derivatives class of drugs.[2]
It was introduced by American Cyanamid under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.[3][4]: 370, 383–384
As of 2015 it was available in Taiwan and Thailand under several brand names.[5]
Fenbufen can be synthesized by acylation of biphenyl with succinic anhydride under Friedel-Crafts conditions.[6]
pyrazolones / pyrazolidines | |
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salicylates | |
acetic acid derivatives and related substances | |
oxicams |
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propionic acid derivatives (profens) |
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n-arylanthranilic acids (fenamates) | |
COX-2 inhibitors (coxibs) | |
other | |
NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |