prostaglandin-E synthase
human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW[1]
Identifiers
EC no.5.3.99.3
CAS no.52227-79-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[2][3]

The synthase generating PGE2 is a membrane-associated protein.

Biosynthesis of eicosanoids.

Isozymes

Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

prostaglandin E synthase (microsomal)
Identifiers
SymbolPTGES
Alt. symbolsMGST1L1
NCBI gene9536
HGNC9599
OMIM605172
RefSeqNM_004878
UniProtO14684
Other data
LocusChr. 9 q34.3
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StructuresSwiss-model
DomainsInterPro
prostaglandin E synthase 2 (microsomal)
Identifiers
SymbolPTGES2
Alt. symbolsC9orf15
NCBI gene80142
HGNC17822
OMIM608152
RefSeqNM_198939
UniProtQ9H7Z7
Other data
LocusChr. 9 q34.12
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StructuresSwiss-model
DomainsInterPro
prostaglandin E synthase 3 (cytosolic)
Identifiers
SymbolPTGES3
Alt. symbolsp23, TEBP, cPGES
NCBI gene10728
HGNC16049
OMIM607061
RefSeqNM_006601
UniProtQ15185
Other data
LocusChr. 12 q13.13
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StructuresSwiss-model
DomainsInterPro

References

  1. ^ Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. Bibcode:2008PNAS..10511110J. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561.
  2. ^ Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931. S2CID 22246484.
  3. ^ Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.

External links


Metabolism: lipid metabolism – eicosanoid metabolism enzymes
Prostanoid signaling modulators
Isomerases: intramolecular oxidoreductases (EC 5.3)
Enzymes
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