Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[2][3]
The synthase generating PGE2 is a membrane-associated protein.
Biosynthesis of eicosanoids.
Isozymes
Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:
Metabolism: lipid metabolism – eicosanoid metabolism enzymes
Prostanoid signaling modulators
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Receptor (ligands) | DP (D2)Tooltip Prostaglandin D2 receptor | DP1Tooltip Prostaglandin D2 receptor 1 | |
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DP2Tooltip Prostaglandin D2 receptor 2 | |
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EP (E2)Tooltip Prostaglandin E2 receptor | EP1Tooltip Prostaglandin EP1 receptor |
- Antagonists: AH-6809
- ONO-8130
- SC-19220
- SC-51089
- SC-51322
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EP2Tooltip Prostaglandin EP2 receptor |
- Antagonists: AH-6809
- PF-04418948
- TG 4-155
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EP3Tooltip Prostaglandin EP3 receptor | |
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EP4Tooltip Prostaglandin EP4 receptor |
- Antagonists: Grapiprant
- GW-627368
- L-161982
- ONO-AE3-208
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Unsorted | |
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FP (F2α)Tooltip Prostaglandin F receptor | |
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IP (I2)Tooltip Prostacyclin receptor | |
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TP (TXA2)Tooltip Thromboxane receptor | |
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Unsorted |
- Arbaprostil
- Ataprost
- Ciprostene
- Clinprost
- Cobiprostone
- Delprostenate
- Deprostil
- Dimoxaprost
- Doxaprost
- Ecraprost
- Eganoprost
- Enisoprost
- Eptaloprost
- Esuberaprost
- Etiproston
- Fenprostalene
- Flunoprost
- Froxiprost
- Lanproston
- Limaprost
- Luprostiol
- Meteneprost
- Mexiprostil
- Naxaprostene
- Nileprost
- Nocloprost
- Ornoprostil
- Oxoprostol
- Penprostene
- Pimilprost
- Piriprost
- Posaraprost
- Prostalene
- Rioprostil
- Rivenprost
- Rosaprostol
- Spiriprostil
- Tiaprost
- Tilsuprost
- Tiprostanide
- Trimoprostil
- Viprostol
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Enzyme (inhibitors) | COX (PTGS) | |
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PGD2STooltip Prostaglandin D synthase | |
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PGESTooltip Prostaglandin E synthase | HQL-79 |
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PGFSTooltip Prostaglandin F synthase | |
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PGI2STooltip Prostacyclin synthase | |
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TXASTooltip Thromboxane A synthase | |
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Others | |
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Isomerases: intramolecular oxidoreductases (EC 5.3)
Enzymes
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Activity | |
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Regulation | |
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Classification | |
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Kinetics | |
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Types | |
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