Clinical data
Trade namesCataflam, Voltaren, Zipsor, others[1]
License data
Routes of
By mouth, rectal, intramuscular, intravenous, topical
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only) / S3 / S2
  • UK: POM (Prescription only) / P / GSL
  • US: ℞-only / OTC[3]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein bindingMore than 99%
MetabolismLiver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation;[7] no active metabolites exist
Onset of actionWithin 4 hours (gel),[4] 30 min (non-gel)[5]
Elimination half-life1.2–2 h (35% of the drug enters enterohepatic recirculation)
Excretion35% bile, 65% urine[6]
  • [2-(2,6-Dichloroanilino)phenyl]acetic acid
CAS Number
PubChem CID
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.035.755 Edit this at Wikidata
Chemical and physical data
Molar mass296.15 g·mol−1
3D model (JSmol)
  • O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl
  • InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) checkY
 ☒NcheckY (what is this?)  (verify)

Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout.[5] It is taken by mouth or rectally in a suppository, used by injection, or applied to the skin.[5][8] Improvements in pain last for as much as eight hours.[5] It is also available in combination with misoprostol in an effort to decrease stomach problems.[9]

Common side effects include abdominal pain, gastrointestinal bleeding, nausea, dizziness, headache, and swelling.[5] Serious side effects may include heart disease, stroke, kidney problems, and stomach ulceration.[9][5] Use is not recommended in the third trimester of pregnancy.[5] It is likely safe during breastfeeding.[9] Diclofenac is believed to work by decreasing the production of prostaglandins, like other drugs in this class.[10]

Diclofenac was patented in 1965 by J.R. Geigy AG;[11][12][verification needed] it came into medical use in the United States in 1988.[5] It is available as a generic medication.[5] In 2020, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.[13][14] It is available as a sodium or potassium salt.[9] It is also widely used for livestock; such use was responsible for the Indian vulture crisis, during which in a few years 95% of the country's vulture population was killed, and in many countries agricultural use is now forbidden.[15][16][17][18]

Medical uses

Diclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea.[19]


Inflammatory disorders may include arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, temporomandibular joint (TMJ) pain, spondylarthritis, ankylosing spondylitis, gout attacks,[20] and pain management in cases of kidney stones and gallstones. An additional indication is the treatment of acute migraines.[21] Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is also present,[20] and is effective against menstrual pain and endometriosis.

Diclofenac is also available in topical forms and has been found to be useful for osteoarthritis but not other types of long-term musculoskeletal pain.[22]

It may also help with actinic keratosis, and acute pain caused by minor strains, sprains, and contusions (bruises).[23]

In many countries,[24] eye drops are sold to treat acute and chronic nonbacterial inflammation of the anterior part of the eyes (such as postoperative states). The eye drops have also been used to manage pain for traumatic corneal abrasion.[25]

Diclofenac is often used to treat chronic pain associated with cancer, especially if inflammation is present.[26] Use of diclofenac gel should not exceed 32 g (32,000 mg) in a day.[27]


Adverse effects

See also: Nonsteroidal anti-inflammatory drug

Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac, ibuprofen and naproxen.[29] Upper gastrointestinal complications were also reported.[29] Major adverse cardiovascular events (MACE) were increased by about a third by diclofenac, chiefly due to an increase in major coronary events.[29] Compared with placebo, of 1000 patients allocated to diclofenac for a year, three more had major vascular events, one of which was fatal.[29] Vascular death was increased significantly by diclofenac.[29]

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[30][31] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[30][31]


In 2013, a study found major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events.[29] Compared with placebo, of 1000 people allocated to diclofenac for a year, three more had major vascular events, one of which was fatal.[29] Vascular death was increased by diclofenac (1·65).[29]

Following the identification of increased risks of heart attacks with the selective COX-2 inhibitor rofecoxib in 2004, attention has focused on all the other members of the NSAIDs group, including diclofenac. Research results are mixed, with a meta-analysis of papers and reports up to April 2006 suggesting a relative increased rate of heart disease of 1.63 compared to nonusers.[32] Professor Peter Weissberg, medical director of the British Heart Foundation said, "However, the increased risk is small, and many patients with chronic debilitating pain may well feel that this small risk is worth taking to relieve their symptoms". Only aspirin was found not to increase the risk of heart disease; however, this is known to have a higher rate of gastric ulceration than diclofenac. In Britain the Medicines and Healthcare products Regulatory Agency (MHRA) said in June 2013 that the drug should not be used by people with serious underlying heart conditions – people who had had heart failure, heart disease or a stroke were advised to stop using it completely.[33] As of 15 January 2015, the MHRA announced that diclofenac will be reclassified as a prescription-only medicine (POM) due to the risk of cardiovascular adverse events.[34]

A subsequent large study of 74,838 Danish users of NSAIDs or coxibs found no additional cardiovascular risk from diclofenac use.[35] A very large study of 1,028,437 Danish users of various NSAIDs or coxibs found the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular death (odds ratio, 1.91; 95% confidence interval, 1.62 to 2.42; and odds ratio, 1.66; 95% confidence interval, 1.06 to 2.59, respectively), with a dose-dependent increase in risk."[36]

Diclofenac is similar in COX-2 selectivity to celecoxib.[37][contradictory]




Mental health

Mechanism of action

As with most NSAIDs, the primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis through COX-inhibition. Diclofenac inhibits COX-1 and COX-2 with relative equipotency.[42]

The main target in inhibition of prostaglandin synthesis appears to be the transiently expressed prostaglandin-endoperoxide synthase-2 (PGES-2) also known as cycloxygenase-2 (COX-2).

It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis.[43]

Diclofenac has a relatively high lipid solubility, making it one of the few NSAIDs that are able to enter the brain by crossing the blood-brain barrier.[44] In the brain, too, it is thought to exert its effect through inhibition of COX-2.[44] In addition, it may have effects inside the spinal cord.[45]

Diclofenac may be a unique member of the NSAIDs in other aspects. Some evidence indicates it inhibits the lipoxygenase pathways,[citation needed] thus reducing formation of the leukotrienes (also pro-inflammatory autacoids). It also may inhibit phospholipase A2 as part of its mechanism of action. These additional actions may explain its high potency – it is the most potent NSAID on a broad basis.[46]

Marked differences exist among NSAIDs in their selective inhibition of the two subtypes of cyclooxygenase, COX-1 and COX-2.[47] Much pharmaceutical drug design has attempted to focus on selective COX-2 inhibition as a way to minimize the gastrointestinal side effects of NSAIDs such as aspirin. In practice, use of some COX-2 inhibitors with their adverse effects has led to massive numbers of patient family lawsuits alleging wrongful death by heart attack, yet other significantly COX-selective NSAIDs, such as diclofenac, have been well tolerated by most of the population.[citation needed]

Besides the COX-inhibition, a number of other molecular targets of diclofenac possibly contributing to its pain-relieving actions have recently been identified. These include:

The action of one single dose is much longer (6 to 8 h) than the very short 1.2–2 h half-life of the drug would indicate. This could be partly because it persists for over 11 hours in synovial fluids.[49]

As a veterinary drug

Diclofenac is widely approved as a veterinary drug. It is used in the treatment of companion animals and livestock. In sheep, pigs, cattle and goats, it is used in the management of several bacterial diseases, including diarrhoea, enteritis, dysentery, foot rot and septicaemia.[50] In some bird species, diclofenac causes accumulation of uric acid crystals in organs, especially kidneys, triggering acute renal necrosis and visceral gout.[51] Vultures, among other carrion-eating birds, are known to scavenge deceased livestock. In South Asia in the 2000s, vulture populations were decimated after feeding on carcasses of livestock that had been treated with diclofenac.[40]

Society and culture


In the United States, 1% diclofenac gel was approved by the FDA in 2007. It was approved as a prescription drug and was indicated for the relief of the pain of osteoarthritis of joints responsive to topical treatment; in particular, it was prescribed for the joints in the hands, knees and feet.[3] It has not been shown to work for strains, sprains, bruises or sports injuries.[3] It was intended for the temporary relief of joint pain due to the most common type of arthritis, osteoarthritis.[3] In February 2020, the gel became an over-the-counter drug and the FDA granted the approval of the nonprescription product to GlaxoSmithKline plc.[3]

Formulations and trade names

The name "diclofenac" derives from its chemical name: 2-(2,6-dichloranilino) phenylacetic acid. Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba-Geigy (now Novartis) in 1973, then in 2015 it was bought by GlaxoSmithKline.[52]

Voltaren and Voltarol contain the sodium salt of diclofenac. In the United Kingdom, Voltarol can be supplied with either the sodium salt or the potassium salt, while Cataflam, sold in some other countries, is the potassium salt only. However, Voltarol Emulgel contains diclofenac diethylammonium, in which a 1.16% concentration is equivalent to a 1% concentration of the sodium salt. In 2016 Voltarol was one of the biggest selling branded over-the-counter medications sold in Great Britain, with sales of £39.3 million.[53]

On 14 January 2015, diclofenac oral preparations were reclassified as prescription-only medicines in the UK. The topical preparations are still available without prescription.[54]

Diclofenac formulations are available worldwide under many different trade names.[1]

Ecological effects

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Main article: Indian vulture crisis

Use of diclofenac for animals is controversial due to toxicity when eaten by scavenging birds that eat dead animals;[15][16] the medication has been banned for veterinary use in several countries.[55][18]

Use of diclofenac in animals has been reported to have led to a sharp decline in the vulture population in the Indian subcontinent – a 95% decline by 2003[56] and a 99.9% decline by 2008. The mechanism is presumed to be renal failure;[57] however, toxicity may be due to direct inhibition of uric acid secretion in vultures.[58] Vultures eat the carcasses of livestock that have been administered veterinary diclofenac, and are poisoned by the accumulated chemical,[59] as vultures do not have a particular enzyme to break down diclofenac. At a meeting of the National Wildlife Board in March 2005, the Government of India announced it intended to phase out the veterinary use of diclofenac.[60] Meloxicam is a safer alternative to replace use of diclofenac.[61] It is more expensive than diclofenac, but the cost is dropping[when?] as more pharmaceutical companies are beginning to manufacture it.[citation needed]

Steppe eagles have the same vulnerability to diclofenac as vultures and may also fall victim to it.[62] Diclofenac has been shown also to harm freshwater fish species such as rainbow trout.[63][64][65][66] In contrast, New World vultures, such as the turkey vulture, can tolerate at least 100 times the level of diclofenac that is lethal to Gyps species.[67]

"The loss of tens of millions of vultures over the last decade has had major ecological consequences across the Indian subcontinent that pose a potential threat to human health. In many places, populations of feral dogs (Canis familiaris) have increased sharply from the disappearance of Gyps vultures as the main scavenger of wild and domestic ungulate carcasses. Associated with the rise in dog numbers is an increased risk of rabies"[61] and casualties of almost 50,000 people.[68] The Government of India cites this as one of the major consequences of a vulture species extinction.[60] A major shift in the transfer of corpse pathogens from vultures to feral dogs and rats could lead to a disease pandemic, causing millions of deaths in a crowded country like India, whereas vultures' digestive systems safely destroy many species of such pathogens. Vultures are long-lived and slow to breed. They start breeding only at the age of six and only 50% of young survive. Even if the government ban is fully implemented, it will take several years to revive the vulture population.[69]

The loss of vultures has had a social impact on the Indian Zoroastrian Parsi community, who traditionally use vultures to dispose of human corpses in Towers of Silence, but are now compelled to seek alternative methods of disposal.[61]

Despite the vulture crisis, diclofenac remains available in other countries including many in Europe.[70] It was controversially approved for veterinary use in Spain in 2013 and continues to be available, despite Spain being home to around 90% of the European vulture population and an independent simulation showing that the drug could reduce the population of vultures by 1–8% annually. Spain's medicine agency presented simulations suggesting that the number of deaths would be quite small.[40][71] A paper published in 2021 identified the first authenticated death of a vulture from diclofenac in Spain, a Cinereous Vulture.[72][16]

Diclofenac is on the European Union's watch list because it pollutes the Baltic Sea. When the substance enters freshwater, it has an environmental impact and is considered more difficult to remove in wastewater treatment plants than, for example, ibuprofen.[73] Harmful residues have been found in blue mussels and fish, among others, where it has been found to cause damage to internal organs such as the gills, kidneys and liver.[74]


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