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In Buddhism, the three marks of existence are three characteristics (Pali: tilakkhaṇa; Sanskrit: त्रिलक्षण trilakṣaṇa) of all existence and beings, namely aniccā (impermanence), dukkha (commonly translated as "suffering", "unsatisfactory," "unease"),[note 1] and anattā (without a lasting essence). That humans are subject to delusion about the three marks, that this delusion results in suffering, and that removal of that delusion results in the end of dukkha, is a central theme in the Buddhist Four Noble Truths and Noble Eightfold Path.
There are different lists of the "marks of existence" found in the canons of the early Buddhist schools.
In the Pali tradition of the Theravada school, the three marks are:
The northern Buddhist Sarvāstivāda tradition meanwhile has the following in their Samyukta Agama:
In the Ekottarika-āgama and in Mahayana sources like the Yogācārabhūmi-Śāstra and The Questions of the Nāga King Sāgara (Sāgaranāgarājaparipṛcchā) however, four characteristics or “four seals of the Dharma” (Sanskrit: dharmoddāna-catuṣṭayaṃ or catvāri dharmapadāni , Chinese: 四法印) are described instead of three: 
Main article: Impermanence
Impermanence (Pali anicca, Sanskrit anitya) means that all things (saṅkhāra) are in a constant state of flux. Buddhism states that all physical and mental events come into being and dissolve. Human life embodies this flux in the aging process and the cycle of repeated birth and death (Samsara); nothing lasts, and everything decays. This is applicable to all beings and their environs, including beings who are reborn in deva (god) and naraka (hell) realms. This is in contrast to nirvana, the reality that is nicca, or knows no change, decay or death.
Main article: Dukkha
Dukkha (Sanskrit duhkha) means [note 2] "unsatisfactory," commonly translated as "suffering, pain." Mahasi Sayadaw calls it 'unmanagable, uncontrollable.'
As the First Noble Truth, dukkha is explicated as the physical and mental dissatisfaction of birth, aging, illness, dying; getting what one wishes to avoid or not getting what one wants; and "in short, the five aggregates of grasping" (skandha).. This, however, is a different context, not the Three Marks of Existence, and therefore 'suffering' may not be the best word for it.
The relationship between the three characteristics is explained in the Pali Canon as follows: What is anicca is dukkha. What is dukkha is anatta (Samyutta Nikaya.Vol4.Page1).
Main article: Anatta
Anatta (Sanskrit anatman) refers to there being no permanent essence in any thing or phenomena, including living beings.
While anicca and dukkha apply to "all conditioned phenomena" (saṅkhārā), anattā has a wider scope because it applies to all dhammās without the "conditioned, unconditioned" qualification. Thus, nirvana too is a state of without Self or anatta. The phrase "sabbe dhamma anatta" includes within its scope each skandha (group of aggregates, heaps) that compose any being, and the belief "I am" is a conceit which must be realized to be impermanent and without substance, to end all dukkha.
The Anattā doctrine of Buddhism denies that there is anything permanent in any person to call one's Self, and that a belief in a Self is a source of Dukkha.  Some Buddhist traditions and scholars, however, interpret the anatta doctrine to be strictly in regard to the five aggregates rather than a universal truth, despite the Buddha affirming so in his first sermon. Religious studies scholar Alexander Wynne calls anattā a "not-self" teaching rather than a "no-self" teaching.
In Buddhism, ignorance (avidyā, or moha; i.e. a failure to grasp directly) of the three marks of existence is regarded as the first link in the overall process of saṃsāra whereby a being is subject to repeated existences in an endless cycle of dukkha. As a consequence, dissolving that ignorance through direct insight into the three marks is said to bring an end to saṃsāra and, as a result, to that dukkha (dukkha nirodha or nirodha sacca, as described in the third of the Four Noble Truths).
Gautama Buddha taught that all beings conditioned by causes (saṅkhāra) are impermanent (anicca) and suffering (dukkha), and that not-self (anattā) characterises all dhammas, meaning there is no "I", "me", or "mine" in either the conditioned or the unconditioned (i.e. nibbāna). The teaching of three marks of existence in the Pali Canon is credited to the Buddha.
All phenomenal existence [in Buddhism] is said to have three interlocking characteristics: impermanence, dukkha and lack of soul, that is, something that does not change.
(...) the three characteristics of samsara/sankhara (the realm of rebirth): anicca (impermance), dukkha (pain) and anatta (no-self).
dukkha (unsatisfactoriness or suffering) (....) In the Introduction I wrote that dukkha is probably best understood as unsatisfactoriness.
(...) anatta is the doctrine of non-self, and is an extreme empiricist doctrine that holds that the notion of an unchanging permanent self is a fiction and has no reality. According to Buddhist doctrine, the individual person consists of five skandhas or heaps - the body, feelings, perceptions, impulses and consciousness. The belief in a self or soul, over these five skandhas, is illusory and the cause of suffering.
(...) Buddha's teaching that beings have no soul, no abiding essence. This 'no-soul doctrine' (anatta-vada) he expounded in his second sermon.