GNB2
Identifiers
AliasesGNB2, G protein subunit beta 2, SSS4, SSS4; NEDHYDF, HG2C1
External IDsOMIM: 139390 MGI: 95784 HomoloGene: 68451 GeneCards: GNB2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005273

NM_010312

RefSeq (protein)

NP_005264

NP_034442

Location (UCSC)Chr 7: 100.67 – 100.68 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.[4][5]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.

This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172354 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
  5. ^ a b "Entrez Gene: GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2".

Further reading