GNAT2
Identifiers
Aliases	GNAT2, ACHM4, GNATC, G protein subunit alpha transducin 2, HG1D
External IDs	OMIM: 139340; MGI: 95779; HomoloGene: 21092; GeneCards: GNAT2; OMA:GNAT2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,603,091 bp[1] End 109,619,929 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.83 cM Start 108,000,105 bp[2] End 108,008,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gonad secondary oocyte testicle apex of heart monocyte islet of Langerhans stromal cell of endometrium blood granulocyte Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens pineal gland islet of Langerhans zygote primary oocyte embryo secondary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding G-protein beta/gamma-subunit complex binding signal transducer activity metal ion binding G protein-coupled photoreceptor activity guanyl nucleotide binding G protein-coupled receptor binding GTPase activity GTP binding Cellular component photoreceptor inner segment plasma membrane photoreceptor outer segment heterotrimeric G-protein complex photoreceptor outer segment membrane Biological process response to stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration retinal cone cell development detection of chemical stimulus involved in sensory perception of bitter taste detection of light stimulus involved in visual perception response to light intensity signal transduction visual perception phototransduction Wnt signaling pathway, calcium modulating pathway protein folding G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2780 14686 Ensembl ENSG00000134183 ENSMUSG00000009108 UniProt P19087 P50149 RefSeq (mRNA) NM_005272 NM_001377295 NM_001379232 NM_008141 RefSeq (protein) NP_005263 NP_001364224 NP_001366161 NP_032167 Location (UCSC) Chr 1: 109.6 – 109.62 Mb Chr 3: 108 – 108.01 Mb PubMed search [3] [4]
Wikidata
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Guanine nucleotide-binding protein G(t) subunit alpha-2 is a protein that in humans is encoded by the GNAT2 gene.^[5][6]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.^[6]

• GeneReviews/NIH/NCBI/UW entry on Achromatopsia
• OMIM entries on Achromatopsia