RHOD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDsOMIM: 605781 MGI: 108446 HomoloGene: 22409 GeneCards: RHOD
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014578
NM_001300886

NM_007485
NM_001329989

RefSeq (protein)

NP_001287815
NP_055393

NP_001316918
NP_031511

Location (UCSC)Chr 11: 67.06 – 67.07 MbChr 19: 4.43 – 4.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RHOD.[6]

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[6]

Interactions

RhoD has been shown to interact with CNKSR1[7] and DIAPH2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173156 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041845 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
  6. ^ a b "Entrez Gene: RHOD ras homolog gene family, member D".
  7. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. United States. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388.
  8. ^ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. England. 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064. S2CID 17891748.

Further reading