Available structures
PDBOrtholog search: PDBe RCSB
AliasesRHOB, ARH6, ARHB, MST081, MSTP081, RHOH6, ras homolog family member B
External IDsOMIM: 165370 MGI: 107949 HomoloGene: 68377 GeneCards: RHOB
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 20.45 – 20.45 MbChr 12: 8.55 – 8.55 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[5][6]

RHOB is a member of the Rho GTP-binding protein family.[7]


RHOB has been shown to interact with CIT,[8] ARHGEF3,[9] ARHGDIG[10] and RHPN2.[11]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143878 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054364 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RHOB ras homolog gene family, member B".
  6. ^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research. 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMC 336400. PMID 3283705.
  7. ^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670.
  8. ^ Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (December 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Letters. 377 (2): 243–8. doi:10.1016/0014-5793(95)01351-2. PMID 8543060.
  9. ^ Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". The Journal of Biological Chemistry. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
  10. ^ Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of Biological Chemistry. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. PMID 8939998.
  11. ^ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). European Journal of Biochemistry. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. PMID 12473120. S2CID 23901713.

Further reading