ATP2B4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATP2B4, ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x, ATPase plasma membrane Ca2+ transporting 4
External IDsOMIM: 108732 MGI: 88111 HomoloGene: 48034 GeneCards: ATP2B4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001684
NM_001001396
NM_001365783
NM_001365784

NM_001167949
NM_213616

RefSeq (protein)

NP_001001396
NP_001675
NP_001352712
NP_001352713

NP_001161421
NP_998781

Location (UCSC)Chr 1: 203.63 – 203.74 MbChr 1: 133.7 – 133.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.[5][6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

Interactions

ATP2B4 has been shown to interact with CASK.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058668 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026463 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (April 1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23". Genomics. 9 (4): 629–41. doi:10.1016/0888-7543(91)90356-J. PMID 1674727.
  6. ^ a b "Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4".
  7. ^ Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L (March 2003). "Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK". The Journal of Biological Chemistry. 278 (11): 9778–83. doi:10.1074/jbc.M212507200. PMID 12511555.

Further reading