ATP2B2
Identifiers
AliasesATP2B2, PMCA2, PMCA2a, PMCA2i, ATPase plasma membrane Ca2+ transporting 2, DFNA82
External IDsOMIM: 108733 MGI: 105368 HomoloGene: 56150 GeneCards: ATP2B2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001331
NM_001683
NM_001330611
NM_001353564
NM_001363862

NM_001036684
NM_009723
NM_001347365

RefSeq (protein)

NP_001001331
NP_001317540
NP_001674
NP_001340493
NP_001350791

NP_001031761
NP_001334294
NP_033853

Location (UCSC)Chr 3: 10.32 – 10.71 MbChr 6: 113.72 – 114.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plasma membrane calcium-transporting ATPase 2 is an enzyme that in humans is encoded by the ATP2B2 gene.[5][6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157087 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030302 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heim R, Hug M, Iwata T, Strehler EE, Carafoli E (May 1992). "Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region". Eur J Biochem. 205 (1): 333–40. doi:10.1111/j.1432-1033.1992.tb16784.x. PMID 1313367.
  6. ^ a b "Entrez Gene: ATP2B2 ATPase, Ca++ transporting, plasma membrane 2".

Further reading