ATP2B2
Identifiers
Aliases	ATP2B2, PMCA2, PMCA2a, PMCA2i, ATPase plasma membrane Ca2+ transporting 2, DFNA82
External IDs	OMIM: 108733 MGI: 105368 HomoloGene: 56150 GeneCards: ATP2B2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,324,023 bp[1] End 10,708,007 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.85 cM Start 113,720,792 bp[2] End 114,019,574 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 46 pons middle temporal gyrus external globus pallidus Brodmann area 23 parietal lobe occipital lobe postcentral gyrus superior frontal gyrus Top expressed in olfactory tubercle cerebellar vermis prefrontal cortex lateral geniculate nucleus superior frontal gyrus medial geniculate nucleus medial dorsal nucleus globus pallidus pontine nuclei primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calcium ion binding metal ion binding calmodulin binding protein C-terminus binding protein binding ATP binding hydrolase activity P-type calcium transporter activity PDZ domain binding P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration Cellular component cytoplasm integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane synapse integral component of plasma membrane cell junction extracellular exosome presynapse postsynaptic density membrane glutamatergic synapse GABA-ergic synapse Biological process regulation of cardiac conduction ion transport ion transmembrane transport neuron differentiation calcium ion transport calcium ion transmembrane transport sensory perception of sound regulation of cytosolic calcium ion concentration transport cellular calcium ion homeostasis regulation of presynaptic cytosolic calcium ion concentration regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 491 11941 Ensembl ENSG00000157087 ENSMUSG00000030302 UniProt Q01814 Q9R0K7 RefSeq (mRNA) NM_001001331 NM_001683 NM_001330611 NM_001353564 NM_001363862 NM_001036684 NM_009723 NM_001347365 RefSeq (protein) NP_001001331 NP_001317540 NP_001674 NP_001340493 NP_001350791 NP_001031761 NP_001334294 NP_033853 Location (UCSC) Chr 3: 10.32 – 10.71 Mb Chr 6: 113.72 – 114.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plasma membrane calcium-transporting ATPase 2 is an enzyme that in humans is encoded by the ATP2B2 gene.^[5][6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]