AliasesKCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13, potassium voltage-gated channel subfamily J member 5, potassium inwardly rectifying channel subfamily J member 5
External IDsOMIM: 600734 MGI: 104755 HomoloGene: 20248 GeneCards: KCNJ5
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 128.89 – 128.92 MbChr 9: 32.23 – 32.26 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

G protein-activated inward rectifier potassium channel 4 (GIRK-4) is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.[5][6]


Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.[6]

In humans KCNJ5 is mainly expressed in adrenal gland and pituitary, although it is also detected at low levels in pancreas, spleen, lung, heart and brain.[7] Consistent with this expression pattern, mutations in KCNJ5/Kir3.4 can cause familial hyperaldosteronism type III and a type of long QT syndrome.[8]


KCNJ5 has been shown to interact with KCNJ3.[9][10]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120457Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032034Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
  6. ^ a b "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5".
  7. ^ "Gtexportal". GETEX portal.
  8. ^ Online Mendelian Inheritance in Man (OMIM): potassium channel, inwardly rectifying, subfamily j, member 5; KCNJ5 - 600734
  9. ^ Huang CL, Jan YN, Jan LY (April 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Letters. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307. S2CID 44072628.
  10. ^ He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (February 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". The Journal of Biological Chemistry. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.