Kyotorphin

Names
IUPAC name (2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5- (diaminomethylideneamino)pentanoic acid
Other names Kiotorphin L-Tyrosyl-L-arginine
Identifiers
CAS Number	70904-56-2 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:17537 Y
ChEMBL	ChEMBL273521 Y
ChemSpider	110353 Y
PubChem CID	123804
UNII	02N30CW3X0 Y
CompTox Dashboard (EPA)	DTXSID40221136
InChI InChI=1S/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1 Y Key: JXNRXNCCROJZFB-RYUDHWBXSA-N Y InChI=1/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1 Key: JXNRXNCCROJZFB-RYUDHWBXBC
SMILES O=C(O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)CCC/N=C(\N)N
Properties
Chemical formula	C15H23N5O4
Molar mass	337.380 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979.^[1] Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that its concentration is lower in patients with persistent pain.^[2]