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Opium poppy (Papaver somniferum) flower
Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex
Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

See also: Components of opium

Structures

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
Chemical structure of 14-hydroxymorphine.
14-Hydroxymorphine
Chemical structure of 2,4-dinitrophenylmorphine.
2,4-Dinitrophenylmorphine
Chemical structure of 6-methyldihydromorphine.
6-Methyldihydromorphine
Chemical structure of 6-methylenedihydrodesoxymorphine.
6-Methylenedihydrodesoxymorphine
Chemical structure of 6-acetyldihydromorphine hydrochloride.
6-Acetyldihydromorphine hydrochloride
Chemical structure of azidomorphine.
Azidomorphine
Chemical structure of chlornaltrexamine.
Chlornaltrexamine
Chemical structure of chloroxymorphamine.
Chloroxymorphamine
Chemical structure of desomorphine.
Desomorphine
(Dihydrodesoxymorphine)
Chemical structure of dihydromorphine.
Dihydromorphine
Chemical structure of ethyldihydromorphine.
Ethyldihydromorphine
Chemical structure of hydromorphinol.
Hydromorphinol
Chemical structure of methyldesorphine.
Methyldesorphine
Chemical structure of N-phenethylnormorphine.
N-Phenethylnormorphine
Chemical structure of 6-nicotinoyldihydromorphine.
6-nicotinoyldihydromorphine
Chemical structure of RAM-378.
RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Chemical structure of acetylpropionylmorphine.
Acetylpropionylmorphine
3,6-Dibutanoylmorphine
Chemical structure of diacetyldihydromorphine.
Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Chemical structure of dibutyrylmorphine.
Dibutyrylmorphine
Chemical structure of dibenzoylmorphine.
Dibenzoylmorphine
Chemical structure of diformylmorphine.
Diformylmorphine
Chemical structure of dipropanoylmorphine.
Dipropanoylmorphine
Chemical structure of heroin.
Heroin
(diacetylmorphine)
Chemical structure of nicomorphine.
Nicomorphine

Codeine-dionine family

Structures

Morphinones and morphols

Structures

Morphides

Structures
Morphides
Chemical structure of alpha-chlorocodide.
α-chlorocodide
Chemical structure of beta-chlorocodide.
β-chlorocodide
Chemical structure of bromomorphide.
Bromomorphide
Chemical structure of chlorodihydrocodide.
Chlorodihydrocodide.
Chemical structure of chloromorphide.
Chloromorphide
Chemical structure of codide.
Codide

Dihydrocodeine series

Structures

Nitrogen morphine derivatives

Structures
Morphides
Chemical structure of 1-nitrocodeine.
1-Nitrocodeine
Chemical structure of codeine-N-oxide.
Codeine-N-oxide
Chemical structure of morphine-N-oxide.
Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Chemical structure of oxymorphazone.
Oxymorphazone

Halogenated morphine derivatives

Structures
Other open chain opioids
Chemical structure of 1-bromocodeine.

1-Bromocodeine

Chemical structure of 1-chlorocodeine.

1-Chlorocodeine

General structure of 1-iodomorphine.

1-Iodomorphine

Active opiate metabolites

Structures

Morphinans

Levomethorphan

Morphinan series

Structures
Other morphinans
Chemical structure of 4-chlorophenylpyridomorphinan
4-chlorophenylpyridomorphinan
Chemical structure of cyclorphan.
Cyclorphan
Chemical structure of dextrallorphan.
Dextrallorphan
Chemical structure of levargorphan
Levargorphan
Chemical structure of levophenacylmorphan.
Levophenacylmorphan
Chemical structure of levomethorphan
Levomethorphan
Chemical structure of norlevorphanol.
Norlevorphanol
Chemical structure of N-methylmorphinan.
N-Methylmorphinan
Chemical structure of oxilorphan.
Oxilorphan
Chemical structure of phenomorphan.
Phenomorphan
Chemical structure of dextromethorphan.
Dextromethorphan
Chemical structure of Levomethorphan.
levomethorphan
Chemical structure of morphanol.
Morphanol
Chemical structure of Ro4-1539.
Ro4-1539
Chemical structure of stephodeline.
Stephodeline
Chemical structure of xorphanol.
Xorphanol

Others

Structures
Other Morphinans
Chemical structure of 1-nitroaknadinine
1-Nitroaknadinine
Chemical structure of 14-episinomenine.
14-episinomenine
Chemical structure of 5,6-dihydronorsalutaridine.
5,6-Dihydronorsalutaridine
Chemical structure of 6-keto-nalbuphine
6-Keto Nalbuphine
Chemical structure of aknadinine.
Aknadinine
Chemical structure of butorphanol
Butorphanol
Chemical structure of cephakicine.
Cephakicine
Chemical structure of cephasamine.
Cephasamine
Chemical structure of cyprodime.
Cyprodime
Chemical structure of drotebanol.
Drotebanol
Chemical structure of fenfangjine G.
Fenfangjine G
Chemical structure of nalbuphine.
Nalbuphine
Chemical structure of sinococuline.
Sinococuline
Chemical structure of sinomenine.
Sinomenine
Chemical structure of tannagine.
Tannagine

Benzomorphans

Structures

4-Phenylpiperidines

Pethidine

Pethidines (meperidines)

Structures

Prodines

Structures

Ketobemidones

Structures

Others

Structures
Other phenylpiperidines
Chemical structure of alvimopan.
Alvimopan
Chemical structure of loperamide.
Loperamide
Chemical structure of LS-115509.
LS-115509
General structure of picenadol.
Picenadol

Open chain opioids

Methadone

Amidones

Structures

Methadols

Structures
Other open chain opioids
Chemical structure of alphaacetylmethadol.

Alphaacetylmethadol

Chemical structure of fimepheptanol.

Dimepheptanol

General structure of levacetylmethadol.

Levacetylmethadol

Chemical structure of noracetylmethadol.

Noracetylmethadol

Moramides

Structures

Thiambutenes

Structures

Phenalkoxams

Structures

Ampromides

Structures

Others

Structures
Other open chain opioids
Chemical structure of embutramide.

Embutramide

Chemical structure of IC-26.

IC-26

Chemical structure of isoaminile.

Isoaminile

General structure of lefetamine.

Lefetamine

Chemical structure of R-4066.

R-4066

Anilidopiperidines

Fentanyl
Structures

Oripavine derivatives

Thienorphine
Thienorphine
Structures

Phenazepanes

Structures

Pirinitramides

Structures
Pirinitramides
Chemical structure of bezitramide.

Bezitramide

Chemical structure of piritramide.

Piritramide

Benzimidazoles

Structures

Indoles

Structures

Beta-Amino Ketones

Structures

Diphenylmethylpiperazines

Structures
Diphenylmethylpiperazines
Chemical structure of BW373U86.

BW373U86

Chemical structure of DPI-221.

DPI-221

Chemical structure of DPI-287.

DPI-287

Chemical structure of DPI-3290.

DPI-3290

Chemical structure of SNC-80.

SNC-80

Opioid peptides

β-neo-endorphin

Dynorphins

Structures

Endomorphins

Endorphins

Structures

Enkephalins

Structures

Propeptides

Others / unknown

Structures

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids

Structures

Combination drug formulations containing opioids

See also

References

  1. ^ ChemIndex CAS Registry Number 3371-56-0
  2. ^ ChemIndex CAS Registry Number 509-56-8
  3. ^ ChemIndex CAS Registry Number 63715-94-6
  4. ^ NCBI PubChem SID 750205
  5. ^ chembase[permanent dead link] cbid_346222
  6. ^ Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. ^ Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.