In computer architecture, 12-bit integers, memory addresses, or other data units are those that are 12 bits (1.5 octets) wide. Also, 12-bit central processing unit (CPU) and arithmetic logic unit (ALU) architectures are those that are based on registers, address buses, or data buses of that size.

Before the widespread adoption of ASCII in the late 1960s, six-bit character codes were common and a 12-bit word, which could hold two characters, was a convenient size. This also made it useful for storing a single decimal digit along with a sign. Possibly the best-known 12-bit CPU is the PDP-8 and its relatives, such as the Intersil 6100 microprocessor produced in various forms from August 1963 to mid-1990. Many analog to digital converters (ADCs) have a 12-bit resolution. Some PIC microcontrollers use a 12-bit word size.

12 binary digits, or 3 nibbles (a 'tribble'), have 4096 (10000 octal, 1000 hexadecimal) distinct combinations. Hence, a microprocessor with 12-bit memory addresses can directly access 4096 words (4 kW) of word-addressable memory. IBM System/360 instruction formats use a 12-bit displacement field which, added to the contents of a base register, can address 4096 bytes of memory in a region that begins at the address in the base register.

List of 12-bit computer systems

• Digital Equipment Corporation
  • PDP-5
  • PDP-8
    • DECmate, a personal computer based on the Intersil 6100
  • PDP-12
  • PDP-14
• Ford EEC I automotive engine control unit
  • Toshiba TLCS-12 microprocessor^[1]
• Intersil IM6100 microprocessor (PDP-8-compatible)
• Control Data Corporation
  • CDC 160 series computers
  • CDC 6600 - Peripheral Processor (PP)
• National Cash Register NCR 315
• Scientific Data Systems SDS 92
• Nuclear Data, Inc. ND812
• PC12 minicomputer
• Ferranti Argus
• LINC, later commercialized by DEC as the LINC-8
• Electronic Arrays 9002 (12-bit addressing but 8-bit byte)