S
Brig. Gen. Stewart ca. 1960
- Sabu – Film actor
- James Salter – Novelist
- Mark Sanford – 115th Governor of South Carolina
- Roy Scheider – Oscar-nominated actor
- Bob Schieffer – Television journalist
- Tex Schramm – President and general manager of the Dallas Cowboys
- Dick Scobee – Astronaut, killed in Space Shuttle Challenger Disaster
- David Scott – Astronaut (Gemini 8, Apollo 9, and Apollo 15)
- Donald E. Scott – All-American college football quarterback
- Dr. Seuss – Famed American children's author, political cartoonist, illustrator, poet, animator and filmmaker
- Lance Sijan – Medal of Honor recipient
- Sinbad – Actor and comedian
- Tom Skerritt – Film actor
- Deke Slayton – Mercury and Apollo-Soyuz Test Project astronaut
- Jack Smight – Theater, film and television director
- Tubby Smith – NCAA Men's Basketball Coach
- Carl Spaatz – Pioneer airman, first Chief of Staff of the Air Force
- Aaron Spelling – Film and television producer
- Mickey Spillane – Crime novelist
- G.D. Spradlin – Film actor known for The Godfather: Part II (1974)
- Thomas P. Stafford – aviator and astronaut (Gemini 6A, Gemini 9A, Apollo 10)
- Bill Stealey – Business CEO and co-founder of MicroProse
- David Steeves – Pilot who crashed in the Sierra Nevada and endured a nearly two month survival ordeal.
- George Steinbrenner – Team owner of the New York Yankees
- Robert Sterling – Film actor
- Craig Stevens – Television actor
- Ted Stevens – Senator of Alaska
- James Stewart – Film actor
- Bert Stiles – Author
- Ralph Story – Television personality
- Dale E. Stovall – USAF General, decorated Vietnam War search and rescue pilot
- John Sturges – Film director
- Chesley Sullenberger – Airline pilot, hero of Miracle on the Hudson
- Bruce Sundlun – 71st governor of Rhode Island
- Charles Sweeney – Pilot who flew the Fat Man bomb to Nagasaki.
- Jack Swigert – Astronaut and congressman-elect