Protein-coding gene in the species Homo sapiens
G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.[5][6][7] GPR128 is a member of the adhesion GPCR family.[8][9]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[11]
Function
Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[12]
Clinical significance
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[13] Notably, the fused gene was also detected in few healthy individuals.