relaxin/insulin-like family peptide receptor 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | RXFP1 | ||||||
Alt. symbols | LGR7 | ||||||
NCBI gene | 59350 | ||||||
HGNC | 19718 | ||||||
OMIM | 606654 | ||||||
RefSeq | NM_021634 | ||||||
UniProt | Q9HBX9 | ||||||
Other data | |||||||
Locus | Chr. 4 q31.3 | ||||||
|
relaxin/insulin-like family peptide receptor 2 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | RXFP2 | ||||||
Alt. symbols | LGR8, GREAT, GPR106, INSL3R | ||||||
NCBI gene | 122042 | ||||||
HGNC | 17318 | ||||||
OMIM | 606655 | ||||||
RefSeq | NM_130806 | ||||||
UniProt | Q8WXD0 | ||||||
Other data | |||||||
Locus | Chr. 13 q12.3 | ||||||
|
relaxin/insulin-like family peptide receptor 3 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | RXFP3 | ||||||
Alt. symbols | RLN3R1, SALPR, GPCR135 | ||||||
NCBI gene | 51289 | ||||||
HGNC | 24883 | ||||||
OMIM | 609445 | ||||||
RefSeq | NM_016568 | ||||||
UniProt | Q9NSD7 | ||||||
Other data | |||||||
Locus | Chr. 5 p15.1-p14 | ||||||
|
relaxin/insulin-like family peptide receptor 4 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | RXFP4 | ||||||
Alt. symbols | GPR100, GPCR142, RLN3R2 | ||||||
NCBI gene | 339403 | ||||||
HGNC | 14666 | ||||||
OMIM | 609043 | ||||||
RefSeq | NM_181885 | ||||||
UniProt | Q8TDU9 | ||||||
Other data | |||||||
Locus | Chr. 1 q22 | ||||||
|
The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
receptor/gene | ligands | activates | inhibits |
---|---|---|---|
RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |