Chloral betaine
Clinical data
Routes of
ATC code
  • None
Legal status
Legal status
  • 2,2,2-Trichloro-1,1-ethanediol : (trimethylammonio)acetate (1:1)
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.017.021 Edit this at Wikidata
Chemical and physical data
Molar mass282.54 g·mol−1
3D model (JSmol)
  • C[N+](C)(C)CC(=O)[O-].C(C(Cl)(Cl)Cl)(O)O
  • InChI=1S/C5H11NO2.C2H3Cl3O2/c1-6(2,3)4-5(7)8;3-2(4,5)1(6)7/h4H2,1-3H3;1,6-7H

Chloral betaine (USAN, BAN) (brand names Beta-Chlor, Somilan), also known as cloral betaine (INN), is a sedative-hypnotic drug.[1][2][3][4] It was introduced by Mead Johnson in the United States in 1963.[5] It is a betaine complex of trimethylglycine with chloral hydrate, which acts as an extended-acting formulation of chloral hydrate which is then metabolized into trichloroethanol, which is responsible for most or all of its effects.[3][4][6]

See also


  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1231–. ISBN 978-1-4757-2085-3.
  2. ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 72–. ISBN 978-94-011-4439-1.
  3. ^ a b Bassuk EL, Schoonover SC, Gelenberg AJ (6 December 2012). The Practitioner's Guide to Psychoactive Drugs. Springer Science & Business Media. pp. 208–. ISBN 978-1-4615-8049-2.
  4. ^ a b Lowry W (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 157–. ISBN 978-1-4684-3444-6.
  5. ^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 944–. ISBN 978-0-8155-1856-3.
  6. ^ Maxwell GM (6 December 2012). Principles of Paediatric Pharmacology. Springer Science & Business Media. pp. 124–. ISBN 978-1-4684-7544-9.