Clinical data
ATC code
  • none
  • 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1,4-benzodiazepine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.047.309 Edit this at Wikidata
Chemical and physical data
Molar mass356.75 g·mol−1
3D model (JSmol)
  • FC1=CC=CC=C1C2=NCCN(CC(F)(F)F)C3=C2C=C(Cl)C=C3
  • InChI=1S/C17H13ClF4N2/c18-11-5-6-15-13(9-11)16(12-3-1-2-4-14(12)19)23-7-8-24(15)10-17(20,21)22/h1-6,9H,7-8,10H2 checkY

Fletazepam[1] is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is mainly notable for its strong muscle relaxant properties.[2]

Fletazepam is most closely related to other N-trifluoroethyl substituted benzodiazepines such as halazepam and quazepam.[3]

See also


  1. ^ DE 2106175, Steinmann, Martin, "Neue 1-Polyfluoralkylbenzodiazepine und Verfahren zu ihrer Herstellung [Novel 1-polyfluoroalkylbenzodiazepines and processes for their preparation]", published 1971-09-30, assigned to Sherico Ltd. 
  2. ^ Barnett A, Goldstein J, Fiedler EP, Taber RI (November 1974). "The pharmacology of fletazepam a centrally-acting muscle relaxant". Archives Internationales de Pharmacodynamie et de Therapie. 212 (1): 164–74. PMID 4476200.
  3. ^ Iorio LC, Barnett A, Billard W (July 1984). "Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites". Life Sciences. 35 (1): 105–13. doi:10.1016/0024-3205(84)90157-7. PMID 6738302.