Protein-coding gene in humans
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[5][6][7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[7]
Function
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[8]
Clinical significance
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[9] eIF1A is mutated in thyroid cancers.[10]
Interactions
EIF1AX has been shown to interact with IPO13.[11]