Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene .[ 5]
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1 -mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4 .[ 6]
IRF2 has been shown to interact with BRD7 ,[ 7] EP300 [ 8] PCAF .[ 8] [ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000168310 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031627 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell . 58 (4): 729–39. doi :10.1016/0092-8674(89)90107-4 . PMID 2475256 . S2CID 2033941 . ^ "Entrez Gene: IRF2 interferon regulatory factor 2" .^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol . 185 (2): 269–79. doi :10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L . PMID 11025449 . S2CID 22932901 . ^ a b Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" . J. Biol. Chem . 276 (24): 20973–80. doi :10.1074/jbc.M101707200 PMID 11304541 . ^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" . Mol. Cell. Biol . 19 (3): 1810–20. doi :10.1128/MCB.19.3.1810 . PMC 83974 PMID 10022868 .
Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie . 80 (8–9): 641–50. doi :10.1016/S0300-9084(99)80017-0 . PMID 9865486 . Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" . Biochimie . 80 (8–9): 651–8. doi :10.1016/S0300-9084(99)80018-2 PMID 9865487 . Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T (1989). "Sequence of a cDNA coding for human IRF-2" . Nucleic Acids Res . 17 (20): 8372. doi :10.1093/nar/17.20.8372 . PMC 334978 PMID 2813069 . Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system" . Mol. Cell. Biol . 14 (2): 1500–9. doi :10.1128/MCB.14.2.1500 . PMC 358505 PMID 7507207 . Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 . Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors" . J. Biol. Chem . 270 (22): 13063–9. doi :10.1074/jbc.270.22.13063 PMID 7768900 . Cha Y, Deisseroth AB (1994). "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region" . J. Biol. Chem . 269 (7): 5279–87. doi :10.1016/S0021-9258(17)37685-8 PMID 8106512 . Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2". Science . 259 (5097): 971–4. Bibcode :1993Sci...259..971H . doi :10.1126/science.8438157 . PMID 8438157 . S2CID 41036818 . Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K (1996). "Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells" . J. Neuroimmunol . 63 (2): 157–62. doi :10.1016/0165-5728(95)00140-9 . PMID 8550813 . S2CID 53166594 . Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo". J. Cell. Biochem . 66 (2): 175–83. doi :10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N . PMID 9213219 . S2CID 34485265 . Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" . Mol. Cell. Biol . 19 (3): 1810–20. doi :10.1128/MCB.19.3.1810 . PMC 83974 PMID 10022868 . Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci . 40 (5): 976–82. PMID 10102295 . Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE (1999). "Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays". Ann. Neurol . 46 (3): 425–8. doi :10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O . PMID 10482277 . S2CID 85574347 . Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia". Leuk. Lymphoma . 35 (5–6): 507–11. doi :10.1080/10428199909169615 . PMID 10609788 . Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol . 185 (2): 269–79. doi :10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L . PMID 11025449 . S2CID 22932901 . Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5". J. Viral Hepat . 8 (2): 103–10. doi :10.1046/j.1365-2893.2001.00273.x . PMID 11264730 . S2CID 55595193 . Masumi A, Ozato K (2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" . J. Biol. Chem . 276 (24): 20973–80. doi :10.1074/jbc.M101707200 PMID 11304541 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
PDB gallery
1irf : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
1irg : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES
2irf : CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
Media related to Interferon regulatory factor-2, IRF-2 at Wikimedia Commons
