CAMK2B
Protein CAMK2B PDB 2ux0.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK2B, CAM2, CAMK2, CAMKB, calcium/calmodulin dependent protein kinase II beta, MRD54, CaMKIIbeta
External IDsOMIM: 607707 MGI: 88257 HomoloGene: 111050 GeneCards: CAMK2B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001174053
NM_001174054
NM_007595

RefSeq (protein)

NP_001167524
NP_001167525
NP_031621

Location (UCSC)Chr 7: 44.22 – 44.33 MbChr 11: 5.92 – 6.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

Function

The enzyme belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.[5]

Interactions

CAMK2B has been shown to interact with Actinin alpha 4.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058404 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057897 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta".
  6. ^ Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. doi:10.1523/JNEUROSCI.21-02-00423.2001. PMC 6763799. PMID 11160423.

Further reading