SGK3
Protein SGK3 PDB 1xte.png
Identifiers
AliasesSGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDsOMIM: 607591 MGI: 2182368 HomoloGene: 56582 GeneCards: SGK3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170709
NM_001033578
NM_013257

NM_001037759
NM_133220
NM_177547

RefSeq (protein)

NP_001191102
NP_001028750
NP_037389
NP_733827

NP_001032848
NP_573483
NP_808215

Location (UCSC)Chr 8: 66.71 – 66.86 MbChr 1: 9.87 – 9.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[5][6][7]

Function

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

In melanocytic cells SGK3 gene expression may be regulated by MITF.[8]

Interactions

SGK3 has been shown to interact with GSK3B.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104205 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025915 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
  6. ^ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  7. ^ a b "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  9. ^ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.

Further reading