MAP3K10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RF0
Identifiers
Aliases	MAP3K10, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10
External IDs	OMIM: 600137 MGI: 1346879 HomoloGene: 1834 GeneCards: MAP3K10
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 40,191,426 bp[1] End 40,215,575 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 27,355,800 bp[2] End 27,374,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus amygdala nucleus accumbens putamen Brodmann area 9 caudate nucleus external globus pallidus hippocampus proper sural nerve Top expressed in superior frontal gyrus cerebellar cortex spermatocyte ganglionic eminence ascending aorta hand secondary oocyte internal carotid artery external carotid artery aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein homodimerization activity transcription corepressor activity kinase activity protein serine/threonine kinase activity bHLH transcription factor binding ATP binding MAP kinase kinase kinase activity JUN kinase kinase kinase activity Cellular component cytoplasm intracellular anatomical structure Biological process phosphorylation positive regulation of JUN kinase activity cell death positive regulation of JNK cascade negative regulation of DNA-binding transcription factor activity protein phosphorylation JNK cascade peptidyl-serine phosphorylation protein autophosphorylation smoothened signaling pathway peptidyl-threonine phosphorylation negative regulation of transcription, DNA-templated signal transduction apoptotic process positive regulation of apoptotic process MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4294 269881 Ensembl ENSG00000130758 ENSMUSG00000040390 UniProt Q02779 Q66L42 RefSeq (mRNA) NM_002446 NM_001081292 NM_001290528 RefSeq (protein) NP_002437 NP_001277457 Location (UCSC) Chr 19: 40.19 – 40.22 Mb Chr 7: 27.36 – 27.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.^[5][6][7]

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.^[7]

Interactions

MAP3K10 has been shown to interact with:

• CDC42,^[8]
• Huntingtin,^[9]
• KIF3A,^[8]
• MAPK8IP1,^[10]
• MAPK8IP2,^[10] and
• NEUROD1.^[11]