CAMK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W4O
Identifiers
Aliases	CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDs	OMIM: 114080 MGI: 88258 HomoloGene: 100780 GeneCards: CAMK4
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.1 Start 111,223,653 bp[1] End 111,494,886 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.15 cM Start 33,067,984 bp[2] End 33,324,281 bp[2]
RNA expression pattern Bgee Top expressed in cerebellar vermis cerebellar hemisphere middle temporal gyrus Ganglionic eminence nucleus accumbens superior frontal gyrus external globus pallidus Brodmann area 23 entorhinal cortex prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity ATP binding Cellular component cytoplasm cytosol nucleoplasm extracellular exosome nucleus fibrillar center postsynapse glutamatergic synapse Biological process GO:0007243 intracellular signal transduction adaptive immune response myeloid dendritic cell cytokine production phosphorylation immune system process myeloid dendritic cell differentiation positive regulation of transcription, DNA-templated regulation of T cell differentiation in thymus protein phosphorylation regulation of osteoclast differentiation long-term memory peptidyl-serine phosphorylation protein autophosphorylation inflammatory response signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	814	12326
Ensembl	ENSG00000152495	ENSMUSG00000038128
UniProt	Q16566	P08414 Q8BGR3
RefSeq (mRNA)	NM_001744 NM_001323374 NM_001323375 NM_001323376 NM_001323377	NM_009793
RefSeq (protein)	NP_001310303 NP_001310304 NP_001310305 NP_001310306 NP_001735	NP_033923
Location (UCSC)	Chr 5: 111.22 – 111.49 Mb	Chr 18: 33.07 – 33.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.^[5]

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.^[6]