PASK
Protein PASK PDB 1ll8.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPASK, PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDsOMIM: 607505 MGI: 2155936 HomoloGene: 9038 GeneCards: PASK
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252119
NM_001252120
NM_001252122
NM_001252124
NM_015148

NM_080850

RefSeq (protein)

NP_001239048
NP_001239049
NP_001239051
NP_001239053
NP_055963

NP_543126

Location (UCSC)Chr 2: 241.11 – 241.15 MbChr 1: 93.24 – 93.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[5][6][7][8]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115687 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026274 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF). Biochem Biophys Res Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972.
  6. ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. doi:10.1073/pnas.161284798. PMC 55361. PMID 11459942.
  7. ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. doi:10.1073/pnas.0307737101. PMC 420392. PMID 15148392.
  8. ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

Further reading