MAPK12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CM8, 4QUM
Identifiers
Aliases	MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDs	OMIM: 602399 MGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,245,450 bp[1] End 50,261,716 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 89,014,787 bp[2] End 89,024,906 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle triceps brachii muscle vastus lateralis muscle thoracic diaphragm anterior pituitary biceps brachii stromal cell of endometrium left uterine tube deltoid muscle cingulate gyrus Top expressed in triceps brachii muscle temporal muscle ankle tibialis anterior muscle vastus lateralis muscle digastric muscle sternocleidomastoid muscle gastrocnemius muscle soleus muscle skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein binding ATP binding magnesium ion binding protein serine/threonine kinase activity MAP kinase activity Cellular component cytosol mitochondrion nucleoplasm nucleus cytoplasm Biological process regulation of transcription, DNA-templated phosphorylation positive regulation of muscle cell differentiation muscle organ development negative regulation of cell cycle transcription, DNA-templated positive regulation of peptidase activity protein phosphorylation peptidyl-serine phosphorylation DNA damage induced protein phosphorylation cell cycle myoblast differentiation signal transduction MAPK cascade regulation of gene expression intracellular signal transduction cellular response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6300 29857 Ensembl ENSG00000188130 ENSMUSG00000022610 UniProt P53778 O08911 RefSeq (mRNA) NM_002969 NM_001303252 NM_013871 RefSeq (protein) NP_001290181 NP_002960 NP_038899 NP_001389948 NP_001389949 NP_001389950 NP_001389951 Location (UCSC) Chr 22: 50.25 – 50.26 Mb Chr 15: 89.01 – 89.02 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.^[5]

Function

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.^[5]