MAPK12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDsOMIM: 602399 MGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002969
NM_001303252

NM_013871

RefSeq (protein)

NP_001290181
NP_002960

NP_038899
NP_001389948
NP_001389949
NP_001389950
NP_001389951

Location (UCSC)Chr 22: 50.25 – 50.26 MbChr 15: 89.01 – 89.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.[5]

Function

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188130 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022610 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: mitogen-activated protein kinase 12".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.