Mitogen-activated protein kinase kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.12.2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).
MAP2K is classified as EC 2.7.12.2.
There are seven genes:
The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.[1] The acronym MEK derives from MAPK/ERK Kinase.[2]
MEK is a member of the MAPK signaling cascade that is activated in melanoma.[3] When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.
MAP kinase activation | |
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Initiation | |
MAP kinase kinase kinase (MAP3K or MKKK) | |
MAP kinase kinase (MAP2K or MKK) | |
MAP kinase | |
Phosphatase |
2.7.1-2.7.4: phosphotransferase/kinase (PO4) |
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2.7.6: diphosphotransferase (P2O7) | |||||||||||||||
2.7.7: nucleotidyltransferase (PO4-nucleoside) |
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2.7.8: miscellaneous |
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2.7.10-2.7.13: protein kinase (PO4; protein acceptor) |
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Activity | |
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Regulation | |
Classification | |
Kinetics | |
Types |
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