PRKAG3
Identifiers
AliasesPRKAG3, AMPKG3, protein kinase AMP-activated non-catalytic subunit gamma 3, SMGMQTL
External IDsMGI: 1891343 HomoloGene: 23006 GeneCards: PRKAG3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017431

NM_153744
NM_153745

RefSeq (protein)

NP_059127

NP_714966

Location (UCSC)Chr 2: 218.82 – 218.83 MbChr 1: 74.78 – 74.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene.[5][6]

Function

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115592 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006542 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Milan D, Jeon JT, Looft C, Amarger V, Robic A, Thelander M, Rogel-Gaillard C, Paul S, Iannuccelli N, Rask L, Ronne H, Lundström K, Reinsch N, Gellin J, Kalm E, Roy PL, Chardon P, Andersson L (May 2000). "A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle". Science. 288 (5469): 1248–51. Bibcode:2000Sci...288.1248M. doi:10.1126/science.288.5469.1248. PMID 10818001.
  6. ^ a b "Entrez Gene: PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit".

Further reading