MAPK4
Identifiers
AliasesMAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDsOMIM: 176949 MGI: 2444559 HomoloGene: 2058 GeneCards: MAPK4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001292039
NM_001292040
NM_002747

NM_172632
NM_001360936

RefSeq (protein)

NP_001278968
NP_001278969
NP_002738

NP_766220
NP_001347865

Location (UCSC)Chr 18: 50.56 – 50.73 MbChr 18: 73.93 – 74.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[5][6]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[6]

The Arabidopsis MAPK4 is important in signalling [7]

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.[8]

References

  1. ^ a b c ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024558 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Li L, Wysk M, Gonzalez FA, Davis RJ (February 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
  6. ^ a b "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
  7. ^ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, et al. (December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111–20. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186. S2CID 1864451.
  8. ^ Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, et al. (March 2019). "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling". The Journal of Clinical Investigation. 129 (3): 1015–1029. doi:10.1172/JCI97712. PMC 6391107. PMID 30688659.

Further reading