Available structures
PDBOrtholog search: PDBe RCSB
AliasesPLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDsOMIM: 602913 MGI: 109604 HomoloGene: 20865 GeneCards: PLK3
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 44.8 – 44.81 MbChr 4: 116.99 – 116.99 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[5][6]


Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[5]


PLK3 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173846 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028680 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".
  6. ^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
  7. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
  8. ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661. S2CID 24106070.
  9. ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.

Further reading