DAPK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE
Identifiers
Aliases	DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDs	OMIM: 616567 MGI: 1341297 HomoloGene: 74940 GeneCards: DAPK2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 63,907,036 bp[1] End 64,072,033 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 C|9 35.75 cM Start 66,158,223 bp[2] End 66,272,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right lung gastrocnemius muscle upper lobe of left lung left ventricle blood sural nerve duodenum hair follicle Top expressed in membranous bone body of femur maxilla lip right lung right lung lobe clavicle human mandible left lung skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity protein binding identical protein binding ATP binding Cellular component cytoplasm autophagosome lumen cytoplasmic vesicle Golgi apparatus intracellular membrane-bounded organelle nucleus Biological process regulation of apoptotic process intracellular signal transduction regulation of intrinsic apoptotic signaling pathway phosphorylation protein phosphorylation positive regulation of eosinophil chemotaxis regulation of autophagy anoikis positive regulation of neutrophil chemotaxis protein autophosphorylation neutrophil migration apoptotic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23604 13143 Ensembl ENSG00000035664 ENSMUSG00000032380 UniProt Q9UIK4 Q8VDF3 RefSeq (mRNA) NM_014326 NM_001363730 NM_001384997 NM_001384998 NM_001384999 NM_001385000 NM_010019 RefSeq (protein) NP_055141 NP_001350659 NP_034149 NP_001391612 Location (UCSC) Chr 15: 63.91 – 64.07 Mb Chr 9: 66.16 – 66.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^[5][6]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.^[6] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.^[7]